Brindha and Rajasekapandiyan 2015/ Phytic acid ameliorates mitochondrial lipid peroxides

Copyright  2015 irjpbs. Aim of the present study is to evaluate the preventive role of phytic acid on mitochondrial lipid peroxides, antioxidants and lipids in isoproterenol (ISO)-induced myocardial infarction (MI) in male Wistar rats. Rats subcutaneously injected with ISO (85 mg/kg) at an interval of 24 h for 2 days resulted in a significant increase in the levels of mitochondrial lipid peroxides with a significant decrease in the activities of mitochondrial antioxidants (SOD, catalase, glutathione peroxidase, glutathione-Stransferase and reduced glutathione). Induction of ISO also showed a significant increase in the levels of mitochondrial cholesterol, triglycerides and free fatty acids with a subsequent decrease in the levels of phospholipids. Oral pretreatment with phytic acid (25 and 50 mg/kg) to ISO-induced rats daily for a period of 56 days significantly decreased the levels of mitochondrial lipid peroxides with a significant increase in the activities of mitochondrial antioxidants and significantly minimized the alterations in the mitochondrial lipid levels in ISO-induced rats. Thus, the findings demonstrate that phytic acid prevents alterations in mitochondrial lipid peroxides, antioxidants and lipids in ISO-induced MI in rats.